I highly doubt in terms of hospitalisation , no . In terms of transmission , highly probable . Vaccine effectiveness in terms of transmission was significantly reduced with omicron , but not in terms of hospitalisation .
Vaccines will be tweaked for mutations . When the over 50s get their winter jab I imagine they will get new vaccines that are tailored to new strains
For the vaccine effectiveness in terms of hospitalisation to fall so much the antigen would have to change so much it would almost have to be like a new virus, I would imagine .