Vaccine level needed to supress "Coronee"

I'd also like some clarifications regarding the headlines in the news outlets regarding the lower efficacy of AZ against the SA variant. If it's still stopping severe illness and they're planning a booster jab in the Autumn, this will not effect our overall plan on coming out of lockdown sometime soon? Can we live with mild symptoms and start lifting restrictions?
 
I'd also like some clarifications regarding the headlines in the news outlets regarding the lower efficacy of AZ against the SA variant. If it's still stopping severe illness and they're planning a booster jab in the Autumn, this will not effect our overall plan on coming out of lockdown sometime soon? Can we live with mild symptoms and start lifting restrictions?
That's the hope. The vaccine had 10% efficacy in a trial of 2000 younger people. None had serious illness, but they were younger.

Petri-dish samples suggest antibodies are produced against the SA virus, which is the hope that there will be sufficient protection.
 
One thing I keep wondering is-will we need herd immunity once all vulnerable groups are vaccinated and protected? I read somewhere that for a reasonably fit person under 50 the chances of dying from Covid are something like 1 in 39,000?
I’m guessing that’s it’s more complicated than I’m imagining but I genuinely wonder why it’s necessary to vaccinate people who aren’t at risk?
You have a good point but I think it’s because you CAN die from it and we don’t have any known and proven treatments yet. So it’s still a risk. People under 40 get flu vaccines too and they don’t often die of flu. That would be my guess.
 
That's the hope. The vaccine had 10% efficacy in a trial of 2000 younger people. None had serious illness, but they were younger.

Petri-dish samples suggest antibodies are produced against the SA virus, which is the hope that there will be sufficient protection.
It should be worth saying as well that because it’s a mutation it doesn’t require a new vaccine, merely and updated version of the current vaccine. Which is why it look like a booster jab will be needed. Even though it’s not fully true I’d consider someone with both original AZ jabs to be fully vaccinated (when deciding reducing lockdown restrictions etc). We have this at the moment with the flu jab. It can’t protect against all mutations of flu but it can provide enough protection to be tolerable
 
I would imagine it may take a couple of years for the virus to get to levels of flu mortalities because, and I am sure Bear and others will correct me if I am wrong, the virus will mutate and change whilst it tries to find a balance between killing it's host and replicating better. Meanwhile we will be developing more and better vaccines. It essentially becomes an arms race and lots of people will have to be producing relevant anti-bodies or be vaccinated against the latest strain.

I would imagine at some point in the future a biological balance is found between host survival and virus reproduction. With an R of 9 and how quickly this is mutating I can't see it be erradicated anytime soon.

Unfortnately I am coming to believe that some controls will be in place next winter and possibly for several winters thereafter.
 
One thing I keep wondering is-will we need herd immunity once all vulnerable groups are vaccinated and protected? I read somewhere that for a reasonably fit person under 50 the chances of dying from Covid are something like 1 in 39,000?
I’m guessing that’s it’s more complicated than I’m imagining but I genuinely wonder why it’s necessary to vaccinate people who aren’t at risk?
Long covid is a thing. It seems to affect previously fit and healthy people disproportionately. No idea on percentage of those affected but it has to be a consideration?
 
It is likely it will mutate to something less dangerous as Spanish flu did after 13 months. There was a lot of moving around in 1918/19 because of WW1. Didn' t we have 3 million people in France that were transported back in 1 month? Spanish Flu spread fast in crowded areas - 12,000 died in 5 weeks in the City of Philadelphia in October 1918 when a group of sailors arrived from New York that must have needed a high R number. If you look at the infection and death rates in 1918/19 and 2020/21 the UK trend line looks similar, with high rates in May 1918 and then a second bigger wave in November 1918 and a smaller third wave in May 1919 (which I hope we will avoid through vaccines).

We lived a 100 years with polio without any lock downs. It was horrible, you probably had 1 in 100,000 chance of getting it if you went in a Public swimming pool in the 1950s (as poor Ian Drury did) . TB killed hundreds every year on Teesside in the 1950s and even 1960s. Poole hospital at Nunthorpe was a TB hospital. My grandad died there in 1958 in his early 50s and my mum said it was packed. We have to live with some very low level risk.

I would vaccinate everyone eventually as the young can still get ill with it and spread it. We have to create a barren environment for CV19 without lock down.

Ref requiring 90/95% herd immunity - its hard to believe only 5% to 10% are naturally immune - in the worst plagues of the middle ages - at least 35% were naturally immune.
 
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