Humour is lost on the likes of Marge.
She has been and still is, one of the most partisan and conspiracy laden political figures in America. Her stupidity precludes her from having any self awareness or humour and hence she sees everything as an attack, no matter if it is or not.
Remember, she confronted a survivor of the Parkland school shootings when he had the temerity to try and get gun control discussions in congress. She's in a constant state of butt hurt and she takes it out on everyone, even kids. Of course, she said she wasn't picking on him and the others, rather his backers such as George Soros, but he's busy with his space lasers and she can't hound him.