Middlesbrough Lockdown Confirmed

[r00fie1]

It is very difficult to convince people who think it is all somehow a fake, not real, and/or caused by 5g. And they quite happily lap up the nonsense that the likes of Piers Corbyn and David Icke spout.

Im sure you are aware of the BNF and NICE Guidelines.
Both are very specific about the physical impacts and contra - indicators of the drug.
We were alerted to the limited evidence available to support the prognosis that it reduced symptoms, but control trials are not far advanced at this point.
I dont waste my time attempting rational conversation with them.

 

[T_A_D]

Im sure you are aware of the BNF and NICE Guidelines.
Both are very specific about the physical impacts and contra - indicators of the drug.
We were alerted to the limited evidence available to support the prognosis that it reduced symptoms, but control trials are not far advanced at this point.
I dont waste my time attempting rational conversation with them.

I agree that giving a drug (lets say hydroxychloroquine) to someone who is seriously ill and maybe being given other drugs too is a very different scenario than giving that same drug to someone healthy to treat malaria. There are drug-drug interactions to consider amongst other things. So why give such a high dose? Am I mis-interpreting the daily doses which were used in the study? Give any drug at a higher dose than its therapeutic window and it will be toxic regardless of contraindications. Give it in too high a dose to healthy people and it will be toxic.

My issue is the way in which studies have been set up. Giving hydroxychloroquine to people who are already seriously ill in hospital is pointless, same for an antiviral (e.g Remdesivir). The proposed mechanism is that the hydroxychlorquine (perhaps plus other medications) prevent viral replication.

Those who do support the use of hydroxychloroquine suggest it should be used early, before the virus takes hold and the subsequent disease. I don't know if it works if used early or not, there have been a number of studies which suggest so (highlighted by Dr Campbell) but as you allude to, control trials are not easy to conduct in this area.

However, on a very basic level even I can tell that giving drugs (hydroxychloroquine and others) that are proposed to act by preventing virus replication will be utterly pointless when used on seriously ill patients who have a disease that has been caused by virus replication!